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Treatment

Kisunla (donanemab)

Quick answer

An anti-amyloid antibody for early symptomatic Alzheimer's disease, given by infusion with MRI monitoring.

Author:
Illinois Dementia Guide editorial team
Medically reviewed by:
Amarish Dave, DO, Board Certified Neurologist
Published:
August 2026
Last medically reviewed:
August 2026
Geographic relevance:
Illinois, United States

Overview

Kisunla targets amyloid plaque and may be stopped once amyloid clearance is achieved on imaging.

Who it is for

  • Biomarker-confirmed early symptomatic Alzheimer's disease
  • Able to complete infusions and MRI surveillance
  • Risk profile reviewed, including APOE4 status and anticoagulant use

What is involved

  • Infusions on a set schedule
  • Periodic amyloid PET to assess clearance
  • Serial MRI to monitor for ARIA

Risks

  • ARIA-E (swelling) and ARIA-H (microbleeds)
  • Infusion-related reactions
  • Rare serious events, including brain hemorrhage

Related resources

Medically reviewed. Last reviewed August 2026. This page is educational information, not individualized medical advice.

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