Overview
Memantine works through a different mechanism than cholinesterase inhibitors and is generally well tolerated.
Practical points
- Often combined with donepezil
- Dose titrated over several weeks
- Adjusted in significant kidney disease
Common side effects
- Dizziness
- Headache
- Confusion or agitation in a minority of patients
- Constipation
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Medically reviewed. Last reviewed August 2026. This page is educational information, not individualized medical advice.